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Anabolic hormonal signaling, including testosterone, growth hormone, and IGF-1

The myonuclei dynamics were very similar between the three ages, but we detected more myonuclei in old and geriatric samples at both days 0 and 7 compared to young (Fig

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These data are particularly interesting since earlier stimulation studies support the role of DBS in promoting neurogenesis through findings that electrical fields can (1) selectively direct the migration of stem cells [377,378,379], (2) increase blood flow [380], and (3) modulate neural networks (see sections by Cooperrider, Manto and Oulad Ben Taib, Bradnam and McCambridge, Popa and Hallett, and Timmann and Nitsche)

Oral peptides are convenient but face a fundamental bioavailability problem: gut acid and peptidases destroy most peptide sequences before they reach blood