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miRNA is a double-edged sword

At the same time, innovations like nanotechnology and mitochondria targeted delivery systems hold promise for increasing efficacy and minimizing systemic side effects

Alternatively, EAAT3 can directly assimilate cysteine

Wang K, Zhang T, Dong Q, Nice EC, Huang C, Wei Y

In further embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulates intracellular NAD+ levels to provide muscular therapy