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Bold values indicate statistical significance

Lancet 364 , 11691171 (2004)

With the agricultural revolution, in the last 10,000 years, and even more recently with industrialization, in the last 200 years, it has been seen: an increase in sodium compared to potassium, as the ratio potassium/sodium has reversed from 10 to 1 to a ratio of 1 to 3 in the modern diet, and in chloride compared to bicarbonate

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Thus, GHRP-2 and Ipamorelin peptides appear to trigger GHS-R1a and potentially stimulate the release of growth hormone