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For lumbar herniations (L4-L5 or L5-S1), inject subcutaneously in the lower back, approximately 1 to 2 inches lateral to the spine at the affected level

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It is hoped that this review will convince scientists and clinicians to look past paracellular permeability to other mechanisms by which endotoxin is taken into the body in the hope that interventions can be devised that prevent endotoxin uptake and that mechanistic interpretations of processes that increased paracellular permeability can be made