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Normal adjustment produces temporary, manageable symptoms that improve with continued use rather than escalating into allergic response

For example, the hydroxylation of proline and lysine residues in collagen by prolyl and lysyl hydroxylase enzymes requires Vitamin C as a cofactor

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Dysbiosis has been associated with reduced therapeutic efficacy, while microbial restoration strategies, such as faecal microbiota transplantation (FMT) and probiotic supplementation, have been shown to enhance immunotherapy outcomes [21]

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