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Description

Podocyte activation of NLRP3 inflammasomes contributes to the development of proteinuria in lupus nephritis

Its unclear what causes them, but overexertion and heat prompt them

DOI: Figure 3figure supplement 1

PS-MPs exacerbated oxidative stress in human vascular endothelial cells (EA.hy926) by downregulating the antioxidant enzyme heme oxygenase-1 (HO-1), disrupting mitochondrial potential, reducing tight junction protein ZO-1, and promoting apoptosis [123]