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MDR can occur both due to alteration of MDR1 gene expression and to increase in the dose of a gene--amplification of a fragment of the genome containing the MDR1 gene and five or six genes linked to it [17]

Some additional regulators, such as epigenetic modifiers, play important roles in the induction and maintenance of the pluripotent state 65

Moreover, in Parkin deficient rodent models, no significant behavioral deficits were observed at either early or later ages (Dave et al., 2.1.3 Movement initiation test (stepping test) Deficits in forepaw movements have been shown to effectively model parkinsonian akinesia, and the type of test commonly used to examine this phenomenon is referred to as the stepping test

7: Andersen NB, Malmlf K, Johansen PB, Andreassen TT, rtoft G, Oxlund H

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