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Blood cfDNA profiling in patients with biliary tract cancer revealed genetic alterations in 84% of cases, with high concordance rates between cfDNA and tumour tissue mutations for specific genes, such as IDH1 or BRAF , though with significantly lower sensitivity for FGFR2 fusions, albeit depending on the respective assays employed 214

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Formulas that rely on stabilized derivatives like ethyl ascorbic acid or ascorbyl glucoside are naturally more resistant to oxidation than pure L-ascorbic acid, no matter where theyre made

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In future, standardized data protocols, explainable AI methodologies, large-scale clinical validation studies, and the establishment of multi-level collaborative networks are needed to promote the translation of this paradigm from theory into clinical practice