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10.1016/j.prenap.2025.100176 Pharmacol Res Nat Prod

However, this doesn't mean copper accumulation is impossible, particularly with long-term use or in individuals with impaired copper metabolism

Indeed, insulin-stimulated phosphorylation of multiple TBC1D4 phosphosites was impaired in insulin-resistant muscle from diabetic or TNF-infused patients [99,100], and conversely, exercise-induced phosphorylation of TBC1D4 S711 was required for improved insulin action in mice [101,102]

To better understand the pharmacokinetics of UDE and its potential to enhance intracellular GSH levels, it is important to conduct in vivo trials that involve administering different doses of UDE at various time intervals

doi: 10.1210/en.2003-0886 62 FosterHD