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Oxidation of cofilin mediates T cell hyporesponsiveness under oxidative stress conditions

Traditional chemotherapy (5-FU, irinotecan, oxaliplatin) lacks selectivity, causing systemic toxicity and immunosuppression despite tumor-agnostic efficacy (96)

Despite their advantageous physiological parallels, constraints such as cost, accessibility, and ethical considerations have prompted the utilization of rodents in this study to establish initial feasibility, while acknowledging the need for subsequent investigations

Identical reads were then combined (dereplication)

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