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Integration of multi-omics datasets with computational frameworks (e.g., weighted gene co-expression network analysis (WGCNA), multi-omics factor analysis (MOFA), and deep-learning models may improve RPL subtype classification, risk prediction, and the identification of potentially actionable pathways

Notably, CB-839 also showed inhibitory effects on AML cells with FLT3 mutation [67]

Mutations in the HFE gene and cardiovascular disease risk

In this case, the gene causing the deficiency does not come from a parent the genetic change happens by chance (1)

To uncover the occurrence of DILI even before human clinical trials, rodents and non-rodents are considered as indispensable preclinical model organisms to test drug safety and hepatic adverse events