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revealed that inhibiting the 15LOX-2/PEBP1 complex, even without directly targeting 15-LOX, can reduce the production of 15-hydroperoxy-eicosatetraenoyl phosphatidylethanolamine (15-HpETE-PE), thereby effectively suppressing lipid peroxidation and ferroptosis ( in vitro and in vivo by specifically targeting the 15LOX-2/PEBP1 complex, which has become a critical target in ferroptosis research (Dar et al., 2023)

GST Tag Interference with Protein Function Challenge : In some cases, the GST tag can interfere with the function of the target protein, particularly if the protein's active site or interaction domains are close to the fusion point

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Moreover, no Met4p or Yap1p analogs were found to regulate GSH1 or GSH2 in S.bacillaris strains