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Compared with other LAs in common clinical use, bupivacaine is more lipophilic and has a greater affinity for the voltage-gated sodium channels

Mufti GR, Aitchison M, Bramwell SP et al: Corporeal plication for surgical correction of Peyronie's disease

Furthermore, the chronic inflammation and immune dysregulation seen in Long COVID and mast cell activation syndrome (MCAS) create a highly toxic environment for the mitochondria