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Spindle pole body component 25 and platelet-derived growth factor mediate crosstalk between tumor-associated macrophages and prostate cancer cells

Such temporal separation matters for target-tissue exposure, since early absorbed conjugates will mainly affect circulating tissues, while colonic-derived metabolites may exert both local gut effects and delayed systemic effects (Zhang et al., 2024a, b)

250,251,252 UA induced inflammation and relative mechanism Uric acid signaling triggers the activation of several transcription factors, such as NF-B or AP-1, through the activation of MAPK p38 and ERK pathways, resulting in the production of reactive oxygen species (ROS) under the conditions of hyperuricemia

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The cell membrane interaction is also important in determining the benefits and limits of liposomes [30]