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Tastuzawa Y, Sekinaka K, Suda T, Matsumoto H, Otabe H, Nonoyama S, et al

Without robust blood flow, the disc's ability to repair itself is profoundly limited

It has been shown that microbially synthesized folate can be partly absorbed across the large intestine in piglets 272

The base mechanism is identical, so if the modified versions really do achieve substantially higher effective tissue concentrations per administered milligram, then a lower administered dose makes sense

The effect is reproducible but typically not dose-defining relative to other covariates (e.g., albumin, tumor burden, time varying clearance)