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B12 is essential for nerve function and can be especially important when deficiency or absorption problems are involved

Many people can fulfill their B12 needs through diet alone

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Rat or mouse bioavailability cannot define human bioavailability

The two methyl groups at the 3- and 5-positions fill a hydrophobic cleft that collapses in the absence of ligand, stabilizing the TM1-TM7 interface in the active conformation