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pH and enzyme dual-responsive release of hydrogen sulfide for disc degeneration therapy

Likewise, HAGSH nanogels enable nanoscale delivery of anti-inflammatory and antimicrobial agents, releasing therapeutic payloads through redox-triggered mechanisms precisely at sites of oxidative imbalance

The increased amount of SH groups damage may be critically important to the function of signal-transduction and transcription events that utilize proteins containing these reactive sites (Brandes et al ., 2009)