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3.6.1 ECM as tissue-engineered scaffolds ECM has a complex 3D microstructure, involving structural proteins such as collagen, fibronectin, and laminin, glycosaminoglycans, and bioactive growth factors, which provide host cell attachment sites and a reservoir of growth factors that encourage cell migration, proliferation, and differentiation [203]

So we just have to have this conversation

35 Because a number of bacterial proteins are Mn dependent, host-mediated Mn sequestration has the potential to disrupt bacterial pathogenesis

That shift is real and measurable in lab studies

Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells