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Therefore, some studies have shown that the level of D-serine in the host may be related to neurological diseases, such as Alzheimers disease, cognitive dysfunction, schizophrenia, depression, and addiction (Holeek, 2022)

For example, DHI, composed of Salvia miltiorrhiza and Carthamus tinctorius in a 3: 1 ratio, can comprehensively alleviate CI/RI in rats by upregulating mitochondrial dynamics-related proteins such as Mfn1, Mfn2, and OPA1 and downregulating apoptosis-related pathway proteins such as Cyt c, Apaf1, Bax, Caspase-3, and Caspase-9 (Du et al., 2023)

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Furthermore, the deletion of Bmal1 in the brain induced apoE expression (inhibiting, e.g., astrocytic clearance of A [73]), potentially elucidating how circadian disruption may increase A burden in the brain