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doi: 10.4161/auto.20764 Summary Keywords reticulocytes, pyruvate kinase deficiency, ferroptosis, mitophagy, GPX4 Citation van Vuren AJ, van Beers EJ and van Wijk R (2021) A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency

Interestingly, administration of TVX to 2D cultured LSECs did not result in decreased viability at all TVX concentrations, indicating that the toxicity in the 3D model is primarily due to direct injury of HepaRG cells and subsequently, as a secondary response, damage to LSECs

It is used to study signaling pathways, molecular interactions and as a tool in the development of analytical methods

GIP is involved in insulin secretion