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Advanced Drug Delivery Reviews, 179, 114097

When Yuyang Liu, a graduate student in his lab and first author of the study, compared SLC25A39s structure against others in the SLC family of transporters in the AlphaFold protein structure database, Liu spotted a unique extra loop in the protein

In another study with 118 CRC patient cases, HO-1 expression was significantly elevated in CRC tumor tissues when compared to paired normal non-tumoral and polyps samples

In reality, interpretation depends on tissue, method, timing and pre-analytical control

In addition, xCT expression can be regulated by the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/PKB/mTOR) 29,30,31 and mitogen-activated protein kinase (MAPK) pathways in synergy with activating transcription factor 4 (ATF4), which is activated by endoplasmic reticulum stress