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H 2 O 2 , derived from the catalytic reduction of the radical anion superoxide (O 2 - ), can be produced by mitochondria and is found in breast milk

Lahiani-Skiba M, Bounoure F, Fessi H, Skiba M

These findings collectively show that astaxanthin, with its high antioxidant characteristics, can be used as an adjuvant treatment in a variety of respiratory disorders, including pneumonia and COVID-19, by lowering oxidative stress and modifying inflammatory responses

FIGURE 4 Novel drug modalities for NRF2 activation Up to date, the only NRF2 activators in clinical use are DMF for MS (Rosito et al., 2020), and more recently Omaveloxolone, a semisynthetic terpenoid with potent NRF2-activating effects gained FDA approval in Februrary 2023 for the treatment of Friederichs ataxia ( However, most NRF2 activators are of electrophilic nature and exhibit unpredictable poly-pharmacology