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Nat Rev Neurosci 8:171181

Silva, L.L.F

While NAD precursors are not stimulants per se, some people report increased alertness or a subtle energy uptick, which is usually welcome in the daytime

These findings unveil a distinct regulatory axis in which nutrient sensing by astrocytes fine-tunes inflammatory and oxidative responses at the level of protein translation, revealing a novel mechanism by which substrate availability modulates enzyme activity during neuroinflammation 123