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Pharmacologically active compounds might bind to the membrane or be taken up into red blood cells, where they can undergo metabolism ( The binding of Pycnogenol constituents and the bioactive microbial metabolite 5-(3,4-dihydroxyphenyl)--valerolactone to human erythrocytes was determined in an in vitro setting ( In a clinical study with 33 patients suffering from severe osteoarthritis 16 patients were allocated to receive 200 mg Pycnogenol per day over 3 weeks before a scheduled knee arthroplasty surgery ( constituents and metabolites were quantified in serum (see section 4.1 Absorption into plasma/serum and concentration profiles), synovial fluid (see section 5.4 Distribution into synovial fluid) and blood cells (Table 2)

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10.1158/1055-9965.EPI-19-0221 116 SchneiderJ