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At a molecular level, MET cKO mice showed altered glutamate receptor expression profiles in the hippocampus at P14, including increased GluA1, GluN2A, and decreased GluN2B at the synaptic sites

Since the dose is higher than what your adrenal glands produce on their own, the cortisol injection has a stronger effect

2003 May;55(5):593-601

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The authors based this study on their preclinical report examining the effect of GABA, DPP-4i and PPI in NOD mice (161)