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Description

Convergent phenotypic evolution towards fosfomycin collateral sensitivity of Pseudomonas aeruginosa antibiotic-resistant mutants

Oral Bioavailability and Metabolic Stability Many bioactive constituents derived from TCM, particularly glycosides (eg, paeoniflorin, forsythoside A) and alkaloids (eg, berberine), exhibit poor oral bioavailability attributable to limited gastrointestinal stability, efflux transporter involvement, and extensive Phase II metabolism including glucuronidation and sulfation