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it is an endogenous fragment, and one line of thinking holds that it may be liberated from larger proteins for example, during tissue injury when extracellular-matrix proteins such as collagen and SPARC (osteonectin) are proteolytically degraded

Fauci AS, Braunwald E, Isselbacher KJ, et al

Maintenance protocol for stable treated disease Scenario: Glaucoma well-controlled on drops, dry AMD stable on AREDS2, diabetic retinopathy non-proliferative with good glucose control

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They are evidenceguided interventions designed to optimize tissue healing and longterm function