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Solution osmolarity is matched to the athletes state isotonic formulations for standard rehydration, slightly hypotonic when cellular water replenishment is the priority to optimize fluid distribution into the intracellular compartment without causing vascular irritation

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Primary literature regarding bioavailability, recommended vehicle type (hydrophilic or lipophilic) and any necessary excipients is essential to determining whether the rectal route is appropriate for a given antibiotic

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