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CSF examination also shows elevated lactate levels in addition to low homovanillic acid (HVA), along with high levels of 3-O-methyldopa, levodopa, and 5-hydroxytryptophan, suggesting the dysfunction of aromatic L-amino acid decarboxylase (AADC)

Results After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was 358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03)

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This rapid, weight-independent improvement in glucose tolerance suggests that disrupting white fat vasculature directly affects metabolic signaling, possibly by interfering with adipokine production or fatty acid metabolism