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Proteasomal activities were measured at an excitation wavelength of 390 nm and an emission wavelength of 460 nm using a Fluoroskan Ascent fluorometer (Thermo Electron, MA) for every 15 min up to 120 min

Though liver is the primary site where CYP2E1-mediated metabolism exerts its most damaging effect, extra-hepatic tissues are often affected to a various degree as well 44,45

Wang D, Li X, Gong G, Lu Y, Guo Z, Chen R, et al

By contrast, the activation of SIRT1 enhances hepatic lipid catabolism and mitochondrial efficiency, serving as a critical counterbalance in the maintenance of metabolic adaptation during NAFLD progression (63)

In addition, antioxidant agents can regulate the signaling process by scavenging ROS in the skin 39