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The percentage of Ki-67 + cells did not differ between the GSTM1 overexpression group and the control group without TGF- stimulation

doi: 10.1172/JCI127721 254 LiXYangKBChenWMaiJWuXQSunTet al

TGF-1 can promote the de-differentiation of epithelial-mesenchymal cells (which normally possess a highly polarized structure for efficient reabsorption of solutes and proteins from the renal tubule into peritubular capillaries), which in turn reduces cell polarity and hence the capability of reabsorption of solutes in the nephron (35)

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The polarization of macrophages can be determined by several environmental factors including cytokines and metabolites such as glutamate