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Its active metabolite, 1 ,25-dihydroxy-vitamin D, modulates the inflammatory response by suppressing pro-inflammatory cytokines (Reference Martens, Gysemans and Verstuyf109) and upregulating anti-inflammatory ones (Reference Calton, Keane and Newsholme110)

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Greifov G, Mjekov H, Greif G, Body P, Greifov M, Dubnikov M

As summarized in the proposed model ( Figure 4 ), mtDNA damage lies at the core of a self-perpetuating cycle that connects early viral and drug insults to the chronic immunometabolic dysfunction that persists throughout HIV infection