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Google Scholar Grace RF, Bianchi P, van Beers EJ

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Introduction Pyruvate Dehydrogenase Complex Function catalyze conversion of pyruvate to acetyl-CoA net reaction pyruvate + NAD + + CoA acetyl-CoA + CO 2 + NADH irreversible Structure 3 enzymes that require 5 cofactors thiamine pyrophosphate (B 1 ) FAD (B 2 ) NAD (B 3 ) CoA (B 5 ) lipoic acid similar to -ketoglutarate dehydrogenase complex Regulation activators of pyruvate dehydrogenase in energy status of the cell NAD+/NADH ratio ADP exercise Ca 2+ insulin inhibited by acetyl-CoA Clinical relevance Overview Pyruvate Dehydrogenase Complex Pyruvate dehydrogenase complex (PDC) is a multi-enzyme complex found in the mitochondria of eukaryotic cells and in the cytoplasm of some bacteria

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Targeting aldose reductase for the treatment of cancer