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A mouse study showed that the inhibition of the proteasomal degradation of T-type Ca v channels by bortezomib and bortezomib-induced increases in the levels of USP5, a deubiquitinating enzyme that specifically inhibits the proteasomal degradation of T-type Ca v channels, increases the protein levels of T-type Ca v channels in nociceptors

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RSO 2 H + H 2 O 2 RSO 3 H + H 2 O Sulfonylation is an irreversible oxidation