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PMID: 31024065 7 Fatal neonatal encephalopathy and lactic acidosis caused by a homozygous loss-of-function variant in COQ9

Furthermore, flies harboring a global null mutation of Ube3a exhibited significant circadian deficits, supporting the notion that Ube3a is an integral component of the Drosophila circadian clock (Wu et al., 2008)

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Kleemann et al., 2011

Although the fold changes of individual genes were modest, the consistent enrichment of these pathways across different databases and the stricter statistical threshold underscore the biological significance of aspirins impact on amino acid metabolism in PIK3CA -mutated cells