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ETHE1 converts GSSH into sulfite and GSH consuming oxygen

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As metabolites are the substrates used to generate chromatin modifications, including methylation and acetylation modifications of histones, a complicated interaction exists between metabolism and epigenetics

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Diet induced obesity (DIO) model and vaccination To induce obesity and metabolic dysfunction, six-week-old male and female K18-hACE2 mice were provided a 60% fat diet (Research Diets #D12492) as replacement for standard mouse chow for a total of 21 weeks