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Although RA patients have abnormally high levels of Treg cells in their synovial fluid (136140), these cells frequently have defective suppressive activity, and certain Foxp3+Treg cells may transform into pathogenic Th17 cells that secrete IL-17, thereby exacerbates inflammatory responses (141)

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PGC-1alpha induces human RPE oxidative metabolism and antioxidant capacity

Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis