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In particular, Lin and colleagues demonstrated that increased methylation levels of these four markers, when combined with the AFP test, had higher diagnostic accuracy in detecting HCC compared to AFP alone (SE: 80% vs 29.5%

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Recently, DCA was shown to promote colorectal carcinoma development by hampering CD8 + T-cell function [131]

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Specifically, HDAC2-driven delactylation of methyltransferase-like 3 (METTL3), a key m6A RNA methyltransferase, enhances m6A methylation associated with DNA damage repair, contributing to cisplatin resistance in triple-negative breast cancer (31)