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The animals were maintained under appropriate temperature conditions of 25 2 C, with a 12-h light/dark cycle, with food (Presence, Neovia, Brazil) and water ad libittum

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This is achieved by alleviating the inhibition of carnitine palmitoyltransferase 1 (CPT1), which is mediated by the local production of malonyl-CoA at the outer membrane of the mitochondria, via ACC2

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TB4 enacts it benefits through the following mechanisms