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What the Research Shows Understanding the mechanism is one thing confirming it actually happens, and by how much, requires looking at real research rather than repeating the claim unsourced, which is what the majority of existing articles on this topic do

* *In a 68- and 72-week clinical trial studying Wegovy (2.4 mg) in patients without diabetes and with BMI 30, or BMI 27 with a weight-related condition, the average weight loss was 15% and 20%, when paired with diet and exercise changes (compared to 2.4% and 3.1%, respectively, with diet and exercise alone)

In the cytoplasm, Keap1 homodimer forms ubiquitin E3 ligase complex with cullin 3 (Cul3), which polyubiquitinates Nrf2 protein leading to its continuous proteasomal degradation ( Figure 3, right)

Shaw et al., 2025)

Medicina 61:61