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The COVID-19 pandemic has further exposed a significant shortfall in diabetes screening and care, emphasizing the urgent need for comprehensive measures to bridge this gap

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INSR B -IGF1R hybrids comprises up to 30% of INSR and IGF-I receptors in muscle due to high expression of both and this hybrid predominantly responds to IGF-I (less to insulin) and explains the important role of IGF-I in growth and metabolism in skeletal muscle

In summary, beneficial Clostridium and their metabolites exert multifaceted protective effects in eight major ADs by regulating gut-immune crosstalk, reinforcing intestinal barrier integrity, and alleviating disease-specific pathological damage, holding great promise as a complementary strategy for clinical immunotherapy