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Acknowledgements R.A.E

Metal ion-based multifunctional nanomaterials demonstrate significant potential for theranostics integration through precise modulation of the tumor microenvironment, enhancement of radiosensitivity, and activation of immune responses

It causes several symptoms including acute and chronic pelvic pain, dysmenorrhea, dyspareunia, abnormal vaginal bleeding, infertility/sterility, and, in severe stages, gastrointestinal and urological symptoms

Pelegrin, P

Structurally, in addition to the effects of hypoxia in pBOO (Stephany et al., 2013), mechanical traction elevates inflammatory mediators such as nuclear factor kappa-B (NF-B), tumor necrosis factor (TNF)-, and interleukin (IL)-6 (Drzewiecki et al., 2012), while ischemia-reperfusion increases oxidative stress in bladder tissue, leading to a surge in reactive oxygen species (ROS) (Miyata et al., 2019)