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However, high adherence to a modified Mediterranean diet (known as the MIND diet) was associated with later age of Parkinson's disease onset (delayed by about 15 to 17 years) in women but not men (Metcalfe-Roach, Mov Disord 2021)

Previously, we showed that simultaneous inhibition of monocarboxylate transporter 1 (MCT-1) and mitochondrial OXPHOS synergistically inhibited the proliferation of several cancer cells 30

77 Additionally, AARS2 also mediates the lactylation of pyruvate dehydrogenase E1 component subunit alpha (PDHA1) at K336 and carnitine palmitoyltransferase 2 (CPT2) at K457/8, leading to the inactivation of both of these enzymes