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Description

In Vivo F344/N rats, including reduced body weight gain, liver and kidney organ weight changes, histopathological lesions in the liver, kidney, nose, and reproductive tract, and significantly reduced survival (0% survival) in male rats at the 40,000 ppm 2-year dose due to exacerbated chronic nephropathy [1]

Numerous minor clinical investigations have indicated elevated AMH, reduced FSH, improved antral follicle count (AFC), and recovery of menstruation, as well as instances of pregnancy after stem cell therapy (Kim and Kim 2024

Of interest, we have recently observed that S -homocysteinylated HSA induces a potent pro-inflammatory response (Nakashima, Shibata, and Uchida, unpublished data)