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Characteristics of the study population BAL fluid samples were obtained from 23 HC, 32 mild-moderate asthma (M/M), and 43 severe asthma (SA) subjects (Table 1) recruited through either Severe Asthma Research Program 3 (SARP3) (HL-109152) or Immune Mechanisms of Severe Asthma (IMSA) (AI-06684)

An alternative approach to diagnosis is to wait until the hemolytic crisis is over and reevaluate the patient after the red blood cell mass is repopulated with cells of all ages (approximately 2 to 3 months)

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Altogether these results indicated that nuclear GSTP restrained HMGB1 cytoplasm translocation through preventing the interaction between cPKC and HMGB1 and attenuating the interaction between HMGB1 and CRM1