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The same reduced-IGFBP-binding property that produces enhanced in vivo potency in animal studies also produces enhanced cell-culture activity, because the IGFBPs secreted into serum-free media by cultured cells otherwise reduce the bioavailability of native IGF-1 supplementation

pmid:19245829 16

9 , 10 Post reduction, Fe +2 is delivered to the cytoplasm by duodenal enterocytes via divalent metal transporter 1 (DMT1), known to be selective for Fe +2 , post which Fe +2 is released into circulation via ferroportin (FPN), the major iron exporter, rendering it available for oxidation by a transmembrane ferroxidase, hephaestin

G., Bladt F., Birchmeier C., et al

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