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10.1038/nrd.2018.115 32 DoohanP

Immunity 54: 15941610 Shao S, Fang H, Duan L, Ye X, Rao S, Han J, Li Y, Yuan G, Liu W, Zhang X (2020) Lysyl hydroxylase 3 increases collagen deposition and promotes pulmonary fibrosis by activating TGFbeta1/Smad3 and Wnt/betacatenin pathways

The activated iodine binds to tyrosine residues on thyroglobulin molecules under the action of TPO to produce monoiodotyrosine (MIT) and diiodotyrosine (DIT), which are subsequently coupled to produce T3 or T4 ( Figure 1 )