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SERMs are non-steroidal estradiol analogs with mixed agonist-antagonist effects on ERs and are used in osteoporosis and breast cancer treatment (Jordan, 2004)

Epub 2010 Sep 5

The Context First lets set the scene of why and how medicines are classified in the UK and the circumstances in which a change might be made

If suspicion of a CMCD is high (clonality prediction score 2), the criterion standard for diagnosing SM or MMAS is a bone marrow biopsy, which should ideally be performed in a center with expertise in SM since the burden of abnormal mast cells is typically quite low in those patients [49, 55, 65]

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