glutathione treatment and parkinson& 39 Frontiers Frontiers | Recent advances in

Hyperactivation of the Akt/mTOR/c-Myc signaling pathway in cancer cells increases the expression of GLUT4, which in turn augments the ability of multidrug resistant cells to rapidly transport and consume glucose through glycolysis (Zhang et al., 2017)

Changes in GST levels have been found to correlate with resistance to anticancer drugs through accelerated detoxification of these drugs' substrates [14]

These phases include specific sets of enzymes and cellular reactions that work to biotransform substances to neutralize, metabolize, and ultimately transport them to be eliminated from the body

Accordingly, it scavenges reactive ROS, and regenerate vitamins C and E, and GSH in their active forms (Kucukgoncu et al., 2017)

In OA animal models, oral or local administration of NAC has been observed to mitigate cartilage damage and pain, closely tied to its role in sustaining GSH levels and inhibiting ferroptosis (92)