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Description

As mentioned in the section above, IDH1 catalyzes typically the conversion of isocitrate to -KG, but the mutant isoform converts -KG into D-2HG instead, which has been shown to inhibit cellular differentiation through epigenetic alterations [19]

The UV spectra of the more hydrophobic compounds 9 , 11 , 12, and 13 were consistent with them being related to flavonoids

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Although the mutant exhibited phenotypes similar to the lpxXL mutant, no difference in the lipid A structure was observed from that in the wild-type strain, indicating that this gene is not involved in the modification of lipid A